Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity

INTRODUCTION: Progranulin (PGRN) is the precursor of granulin (GRN), a soluble cofactor for toll-like receptor 9 (TLR9) signaling evoked by oligonucleotide (CpG)-DNA. Because TLR9 signaling plays an important role in systemic lupus erythematosus (SLE), we investigated whether PGRN is involved in the...

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Autori principali: Tanaka, Atsushi, Tsukamoto, Hiroshi, Mitoma, Hiroki, Kiyohara, Chikako, Ueda, Naoyasu, Ayano, Masahiro, Ohta, Shun-ichiro, Inoue, Yasushi, Arinobu, Yojirou, Niiro, Hiroaki, Horiuchi, Takahiko, Akashi, Koichi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674629/
https://ncbi.nlm.nih.gov/pubmed/23140401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4087
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