Identification of a small molecule 1,4-bis-[4-(3-phenoxy-propoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53

AIM: To identify novel small compound inhibitor of p53 protein. METHODS: Mouse embryonic fibroblasts (MEF) and mouse embryonic stem (ES) cells were tested. Cell proliferation rate was determined using a Cell Proliferation Kit. The mRNA and protein levels of p53-related genes were measured using real...

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Main Authors: Liu, Xin, Zhang, Ying, Tong, Man, Liu, Xiu-ying, Luo, Guan-zheng, Xie, Dong-fang, Ren, Shao-fang, Bai, Dong-hui, Wang, Liu, Zhou, Qi, Wang, Xiu-jie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674519/
https://ncbi.nlm.nih.gov/pubmed/23736005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2013.61
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