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Disulfide reduction abolishes tissue factor cofactor function
BACKGROUND: Tissue factor (TF), an in vivo initiator of blood coagulation, is a transmembrane protein and has two disulfides in the extracellular domain. The integrity of one cysteine pair, Cys186–Cys209, has been hypothesized to be essential for an allosteric “decryption” phenomenon, presumably reg...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674504/ https://ncbi.nlm.nih.gov/pubmed/23434438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.02.013 |
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