EGFR and K-Ras Mutations and Resistance of Lung Cancer to IGF-1R Tyrosine Kinase Inhibitors

BACKGROUND: Most patients with non–small cell lung cancer (NSCLC) have responded poorly to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We investigated the involvement of insulin-like growth factor 1 receptor (IGF-1R) signaling in primary resistance to EGFR TKIs and the...

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Detalhes bibliográficos
Main Authors: Kim, Woo-Young, Prudkin, Ludmila, Feng, Lei, Kim, Edward S., Hennessy, Bryan, Lee, Ju-Seog, Lee, J. Jack, Glisson, Bonnie, Lippman, Scott M., Wistuba, Ignacio I., Hong, Waun Ki, Lee, Ho-Young
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674414/
https://ncbi.nlm.nih.gov/pubmed/22359227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.26656
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