B-cell translocation gene 2 positively regulates GLP-1-stimulated insulin secretion via induction of PDX-1 in pancreatic β-cells

Glucagon-like peptide-1 (GLP-1) is a potent glucoincretin hormone and an important agent for the treatment of type 2 diabetes. Here we demonstrate that B-cell translocation gene 2 (BTG2) is a crucial regulator in GLP-1-induced insulin gene expression and insulin secretion via upregulation of pancrea...

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Bibliographic Details
Main Authors: Hwang, Seung-Lark, Kwon, Okyun, Kim, Sun-Gyun, Lee, In-Kyu, Kim, Yong Deuk
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674408/
https://ncbi.nlm.nih.gov/pubmed/23703573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2013.47
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