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Viral counterattack against the host innate immune system

Paramyxoviruses evade antiviral immune response using a small nonstructural protein, V, which binds to the host dsRNA sensor MDA5 and prevents it from activating the interferon signaling pathway. A recent crystal structure of the V protein in complex with MDA5, published in Science, revealed that V...

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Autors principals: Wu, Bin, Hur, Sun
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674382/
https://ncbi.nlm.nih.gov/pubmed/23478300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2013.32
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