Neuroglobin Overexpression Inhibits Oxygen-Glucose Deprivation-induced Mitochondrial Permeability Transition Pore Opening in Primary Cultured Mouse Cortical Neurons

Neuroglobin (Ngb) is an endogenous neuroprotective molecule against hypoxic/ischemic brain injury, but the underlying mechanisms remain largely undefined. Our recent study revealed that Ngb can bind to voltage-dependent anion channel (VDAC), a regulator of mitochondria permeability transition (MPT)....

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Main Authors: Yu, Zhanyang, Liu, Ning, Li, Yadan, Xu, Jianfeng, Wang, Xiaoying
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674158/
https://ncbi.nlm.nih.gov/pubmed/23639789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.04.015
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