Prediction of Clinically Relevant Safety Signals of Nephrotoxicity through Plasma Metabolite Profiling

Addressing safety concerns such as drug-induced kidney injury (DIKI) early in the drug pharmaceutical development process ensures both patient safety and efficient clinical development. We describe a unique adjunct to standard safety assessment wherein the metabolite profile of treated animals is co...

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Main Authors: Mattes, W. B., Kamp, H. G., Fabian, E., Herold, M., Krennrich, G., Looser, R., Mellert, W., Prokoudine, A., Strauss, V., van Ravenzwaay, B., Walk, T., Naraoka, H., Omura, K., Schuppe-Koistinen, I., Nadanaciva, S., Bush, E. D., Moeller, N., Ruiz-Noppinger, P., Piccoli, S. P.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3673329/
https://ncbi.nlm.nih.gov/pubmed/23762827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/202497
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