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An extracellular steric seeding mechanism for Eph-ephrin signalling platform assembly
Erythropoetin-producing hepatoma (Eph) receptors are cell surface protein tyrosine kinases mediating cell-cell communication. Upon activation they form signalling clusters. We report crystal structures of the full ectodomain of human EphA2 (eEphA2), alone and in complex with the receptor-binding dom...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3672960/ https://ncbi.nlm.nih.gov/pubmed/20228801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1782 |
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