Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models

INTRODUCTION: Targeting receptor tyrosine kinases (RTKs) with kinase inhibitors is a clinically validated anti-cancer approach. However, blocking one signaling pathway is often not sufficient to cause tumor regression and the effectiveness of individual inhibitors is often short-lived. As alteration...

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Main Authors: Issa, Amine, Gill, Jason W, Heideman, Marinus R, Sahin, Ozgur, Wiemann, Stefan, Dey, Julien H, Hynes, Nancy E
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672810/
https://ncbi.nlm.nih.gov/pubmed/23343422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3379
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