HIF-1α stimulates aromatase expression driven by prostaglandin E(2 )in breast adipose stroma

INTRODUCTION: The majority of postmenopausal breast cancers are estrogen-dependent. Tumor-derived factors, such as prostaglandin E(2 )(PGE(2)), stimulate CREB1 binding to cAMP response elements (CREs) on aromatase promoter II (PII), leading to the increased expression of aromatase and biosynthesis o...

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Main Authors: Samarajeewa, Nirukshi U, Yang, Fangyuan, Docanto, Maria M, Sakurai, Minako, McNamara, Keely M, Sasano, Hironobu, Fox, Stephen B, Simpson, Evan R, Brown, Kristy A
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672802/
https://ncbi.nlm.nih.gov/pubmed/23566437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr3410
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