MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes

INTRODUCTION: Increased expression of aggrecanase-1 (ADAMTS-4) has emerged as an important factor in osteoarthritis (OA) and other joint diseases. This study aimed to determine whether the expression of ADAMTS-4 in human chondrocytes is regulated by miRNA. METHODS: MiRNA targets were identified usin...

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Hauptverfasser: Matsukawa, Tetsuya, Sakai, Tadahiro, Yonezawa, Tomo, Hiraiwa, Hideki, Hamada, Takashi, Nakashima, Motoshige, Ono, Yohei, Ishizuka, Shinya, Nakahara, Hiroyuki, Lotz, Martin K, Asahara, Hiroshi, Ishiguro, Naoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672767/
https://ncbi.nlm.nih.gov/pubmed/23406982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4164
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