Denosumab and Bone Metastasis-Free Survival in Men With Castration-Resistant Prostate Cancer: Results of a Global Phase 3, Randomised, Placebo-Controlled Trial

BACKGROUND: Bone metastases are a major cause of morbidity and mortality in men with prostate cancer. Preclinical studies suggest that osteoclast inhibition may prevent bone metastases. This phase 3 study evaluated denosumab, a fully human anti-RANKL monoclonal antibody, to prevent bone metastasis o...

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Hauptverfasser: Smith, Matthew R, Saad, Fred, Coleman, Robert, Shore, Neal, Fizazi, Karim, Tombal, Bertrand, Miller, Kurt, Sieber, Paul, Karsh, Lawrence, Damião, Ronaldo, Tammela, Teuvo L, Egerdie, Blair, Van Poppel, Hendrik, Chin, Joseph, Morote, Juan, Gómez-Veiga, Francisco, Borkowski, Tomasz, Ye, Zhishen, Kupic, Amy, Dansey, Roger, Goessl, Carsten
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671878/
https://ncbi.nlm.nih.gov/pubmed/22093187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(11)61226-9
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