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The P66Shc/Mitochondrial Permeability Transition Pore Pathway Determines Neurodegeneration
Mitochondrial-mediated oxidative stress and apoptosis play a crucial role in neurodegenerative disease and aging. Both mitochondrial permeability transition (PT) and swelling of mitochondria have been involved in neurodegeneration. Indeed, knockout mice for cyclophilin-D (Cyc-D), a key regulatory co...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Hindawi Publishing Corporation
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671270/ https://ncbi.nlm.nih.gov/pubmed/23766859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/719407 |
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