Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice

Slow-twitch muscles, devoted to postural maintenance, experience atrophy and weakness during muscle disuse due to bed-rest, aging or spaceflight. These conditions impair motion activities and can have survival implications. Human and animal studies demonstrate the anabolic role of IGF-1 on skeletal...

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Main Authors: Pierno, Sabata, Camerino, Giulia M., Cannone, Maria, Liantonio, Antonella, De Bellis, Michela, Digennaro, Claudio, Gramegna, Gianluca, De Luca, Annamaria, Germinario, Elena, Danieli-Betto, Daniela, Betto, Romeo, Dobrowolny, Gabriella, Rizzuto, Emanuele, Musarò, Antonio, Desaphy, Jean-François, Camerino, Diana Conte
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670938/
https://ncbi.nlm.nih.gov/pubmed/23755187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065167
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