Effects of Sample Size on Differential Gene Expression, Rank Order and Prediction Accuracy of a Gene Signature

Top differentially expressed gene lists are often inconsistent between studies and it has been suggested that small sample sizes contribute to lack of reproducibility and poor prediction accuracy in discriminative models. We considered sex differences (69♂, 65♀) in 134 human skeletal muscle biopsies...

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Bibliographic Details
Main Authors: Stretch, Cynthia, Khan, Sheehan, Asgarian, Nasimeh, Eisner, Roman, Vaisipour, Saman, Damaraju, Sambasivarao, Graham, Kathryn, Bathe, Oliver F., Steed, Helen, Greiner, Russell, Baracos, Vickie E.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670871/
https://ncbi.nlm.nih.gov/pubmed/23755224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065380
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