Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

BACKGROUND: We examined the potential of metformin (MET) to enhance non-small cell lung cancer (NSCLC) responses to ionising radiation (IR). METHODS: Human NSCLC cells, mouse embryonic fibroblasts from wild-type and AMP-activated kinase (AMPK) α1/2-subunit(−/−) embryos (AMPKα1/2(−/−)-MEFs) and NSCLC...

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Detalhes bibliográficos
Main Authors: Storozhuk, Y, Hopmans, S N, Sanli, T, Barron, C, Tsiani, E, Cutz, J-C, Pond, G, Wright, J, Singh, G, Tsakiridis, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670487/
https://ncbi.nlm.nih.gov/pubmed/23632475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.187
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