Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222

BACKGROUND: Most of the heritable risk of glioma is presently unaccounted for by mutations in known genes. In addition to rare inactivating germline mutations in TP53 causing glioma in the context of the Li-Fraumeni syndrome, polymorphic variation in TP53 may also contribute to the risk of developin...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Enciso-Mora, V, Hosking, F J, Di Stefano, A L, Zelenika, D, Shete, S, Broderick, P, Idbaih, A, Delattre, J-Y, Hoang-Xuan, K, Marie, Y, Labussière, M, Alentorn, A, Ciccarino, P, Rossetto, M, Armstrong, G, Liu, Y, Gousias, K, Schramm, J, Lau, C, Hepworth, S J, Schoemaker, M, Strauch, K, Müller-Nurasyid, M, Schreiber, S, Franke, A, Moebus, S, Eisele, L, Swerdlow, A, Simon, M, Bondy, M, Lathrop, M, Sanson, M, Houlston, R S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Genetics and Genomics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670481/
https://ncbi.nlm.nih.gov/pubmed/23571737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.155
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