Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells.

The chromatin structure of the interleukin-2 (IL-2) gene was probed by DNase I treatment of isolated nuclei. The 5' region of the IL-2 gene contains three regions of hypersensitivity to DNase I. When peripheral blood T cells or Jurkat T cells are stimulated with mitogens, IL-2 message is induce...

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Autors principals: Siebenlist, U, Durand, D B, Bressler, P, Holbrook, N J, Norris, C A, Kamoun, M, Kant, J A, Crabtree, G R
Format: Artigo
Idioma:Inglês
Publicat: 1986
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC367038/
https://ncbi.nlm.nih.gov/pubmed/3491296
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