Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

We recently reported the isolation of a scorpion toxin named U(1)-liotoxin-Lw1a (U(1)-LITX-Lw1a) that adopts an unusual 3D fold termed the disulfide-directed hairpin (DDH) motif, which is the proposed evolutionary structural precursor of the three-disulfide-containing inhibitor cystine knot (ICK) mo...

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Detalhes bibliográficos
Main Authors: Smith, Jennifer J., Vetter, Irina, Lewis, Richard J., Peigneur, Steve, Tytgat, Jan, Lam, Alexander, Gallant, Esther M., Beard, Nicole A., Alewood, Paul F., Dulhunty, Angela F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670328/
https://ncbi.nlm.nih.gov/pubmed/23671114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214062110
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