Structure of the Leanyer orthobunyavirus nucleoprotein–RNA complex reveals unique architecture for RNA encapsidation

Negative-stranded RNA viruses cover their genome with nucleoprotein (N) to protect it from the human innate immune system. Abrogation of the function of N offers a unique opportunity to combat the spread of the viruses. Here, we describe a unique fold of N from Leanyer virus (LEAV, Orthobunyavirus g...

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Detalhes bibliográficos
Main Authors: Niu, Fengfeng, Shaw, Neil, Wang, Yao E., Jiao, Lianying, Ding, Wei, Li, Xiaomin, Zhu, Ping, Upur, Halmurat, Ouyang, Songying, Cheng, Genhong, Liu, Zhi-Jie
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670306/
https://ncbi.nlm.nih.gov/pubmed/23569220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300035110
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