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Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis

Sulfiredoxin (Srx) is the enzyme that reduces the hyperoxidized inactive form of peroxiredoxins. To study the function of Srx in carcinogenesis in vivo, we tested whether loss of Srx protects mice from cancer development. Srx null mice were generated and colon carcinogenesis was induced by an azoxym...

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Detalhes bibliográficos
Main Authors: Wei, Qiou, Jiang, Hong, Baker, Alyson, Dodge, Lisa K., Gerard, Matthieu, Young, Matthew R., Toledano, Michel B., Colburn, Nancy H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670259/
https://ncbi.nlm.nih.gov/pubmed/23393226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt059
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