Assessment of proarrhythmic activity of chloroquine in in vivo and ex vivo rabbit models

OBJECTIVES: To evaluate the prolongation of ventricular repolarization and proarrhythmic activity of antimalarial drug chloroquine in two rabbit proarrhythmia models viz., in vivo α1 adrenoceptor-stimulated anesthetized rabbit and ex vivo isolated Langendorff rabbit heart using clofilium as standard...

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Hlavní autoři: Khobragade, Shailaja B., Gupta, Pankaj, Gurav, Prashant, Chaudhari, Girish, Gatne, Madhumanjiri M., Shingatgeri, Vyas M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Medknow Publications & Media Pvt Ltd 2013
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669570/
https://ncbi.nlm.nih.gov/pubmed/23759957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0976-500X.110892
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