Dasatinib targets chronic myeloid leukemia-CD34(+) progenitors as effectively as it targets mature cells

Dasatinib is effective in most chronic phase chronic myeloid leukemia patients both in first-line therapy and following imatinib failure. While imatinib uptake into CD34(+) cells is low compared to mononuclear cells, few data evaluate how well dasatinib targets primitive CML cells. This study compar...

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Detalhes bibliográficos
Main Authors: Hiwase, Devendra K., Saunders, Verity A., Nievergall, Eva, Ross, Douglas D., White, Deborah L., Hughes, Timothy P.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3669445/
https://ncbi.nlm.nih.gov/pubmed/23065516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.070268
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