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Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth
Glioblastomas (GBMs) are very aggressive tumors that are resistant to conventional chemo- and radiotherapy. New molecular therapeutic strategies are required to effectively eliminate the subpopulation of GBM tumor–initiating cells that are responsible for relapse. Since EGFR is altered in 50% of GBM...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3668845/ https://ncbi.nlm.nih.gov/pubmed/23635774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63623 |
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