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Diabetes-induced Central Neuritic Dystrophy and Cognitive Deficits Are Associated with the Formation of Oligomeric Reticulon-3 via Oxidative Stress

Diabetes is a high risk factor to dementia. To investigate the molecular mechanism of diabetic dementia, we induced type 2 diabetes in rats and examined potential changes in their cognitive functions and the neural morphology of the brains. We found that the diabetic rats with an impairment of spati...

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Detalhes bibliográficos
Main Authors: Zhao, Bei, Pan, Bai-Shen, Shen, Su-Wen, Sun, Xiao, Hou, Zheng-Zhou, Yan, Riqiang, Sun, Feng-Yan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668720/
https://ncbi.nlm.nih.gov/pubmed/23592790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.440784
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