BCL6 breaks occur at different AID sequence motifs in Ig–BCL6 and non-Ig–BCL6 rearrangements

BCL6 translocations are common in B-cell lymphomas and frequently have chromosomal breaks in immunoglobulin heavy chain (IgH) switch regions, suggesting that they occur during class-switch recombination. We analyze 120 BCL6 translocation breakpoints clustered in a 2156-bp segment of BCL6 intron 1, i...

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Autors principals: Lu, Zhengfei, Tsai, Albert G., Akasaka, Takashi, Ohno, Hitoshi, Jiang, Yanwen, Melnick, Ari M., Greisman, Harvey A., Lieber, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668488/
https://ncbi.nlm.nih.gov/pubmed/23476051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-10-464958
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