Analysis of the potential effect of ponatinib on the QTc interval in patients with refractory hematological malignancies

PURPOSE: Cardiac dysfunction, particularly QT interval prolongation, has been observed with tyrosine kinase inhibitors approved to treat chronic myeloid leukemia. This study examines the effects of ponatinib on cardiac repolarization in patients with refractory hematological malignancies enrolled in...

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Detalhes bibliográficos
Main Authors: Sonnichsen, Daryl, Dorer, David J., Cortes, Jorge, Talpaz, Moshe, Deininger, Michael W., Shah, Neil P., Kantarjian, Hagop M., Bixby, Dale, Mauro, Michael J., Flinn, Ian W., Litwin, Jeffrey, Turner, Christopher D., Haluska, Frank G.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668123/
https://ncbi.nlm.nih.gov/pubmed/23609479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2160-7
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