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Nonmyofilament-Associated Troponin T3 Nuclear and Nucleolar Localization Sequence and Leucine Zipper Domain Mediate Muscle Cell Apoptosis

Troponin T (TnT) plays a major role in striated muscle contraction. We recently demonstrated that the fast skeletal muscle TnT3 isoform is localized in the muscle nucleus, and either its full-length or COOH-terminus leads to muscle cell apoptosis. Here, we further explored the mechanism by which it...

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Bibliografske podrobnosti
Main Authors: Zhang, Tan, Birbrair, Alexander, Delbono, Osvaldo
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667714/
https://ncbi.nlm.nih.gov/pubmed/23378072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.21095
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