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The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin
Animals detect and reject their first essential/indispensable amino acid (IAA) deficient meal within 20 min; this IAA sensing requires an intact anterior piriform cortex (APC). In the biochemical responses to IAA deficiency in the APC we have shown that: uncharged tRNA is the primary sensor; IAA tra...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3667674/ https://ncbi.nlm.nih.gov/pubmed/19800362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2009.09.014 |
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