CD8(+) Granzyme B(+)–Mediated Tissue Injury vs. CD4(+)IFNγ(+)–Mediated Parasite Killing in Human Cutaneous Leishmaniasis

A protective or deleterious role of CD8(+)T cells in human cutaneous leishmaniasis (CL) has been debated. The present report explores the participation of CD8(+)T cells in disease pathogenesis as well as in parasite killing. CD8(+)T cells accumulated in CL lesions as suggested by a higher frequency...

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Detalhes bibliográficos
Main Authors: Santos, Claire da Silva, Boaventura, Viviane, Ribeiro Cardoso, Cristina, Tavares, Natalia, Lordelo, Morgana J, Noronha, Almério, Costa, Jackson, Borges, Valéria M., de Oliveira, Camila I, Van Weyenbergh, Johan, Barral, Aldina, Barral-Netto, Manoel, Brodskyn, Cláudia Ida
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3667352/
https://ncbi.nlm.nih.gov/pubmed/23321919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.4
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