Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis

Deregulated Toll-like receptor (TLR)-triggered inflammatory responses that depend on NF-κB are detrimental to the host via excessive production of proinflammatory cytokines, including TNF-α. Stat2 is a critical component of type I IFN signaling, but it is not thought to participate in TLR signaling....

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Detalhes bibliográficos
Main Authors: Alazawi, William, Heath, Helen, Waters, Jennifer A., Woodfin, Abigail, O’Brien, Alastair J., Scarzello, Anthony J., Ma, Bin, Lopez-Otalora, Yolanda, Jacobs, Michael, Petts, Gemma, Goldin, Robert D., Nourshargh, Sussan, Gamero, Ana M., Foster, Graham R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666758/
https://ncbi.nlm.nih.gov/pubmed/23653476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221652110
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