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Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA

The regulated binding of effector proteins to the nucleosome plays a central role in the activation and silencing of eukaryotic genes. How this binding changes the properties of chromatin to mediate gene activation or silencing is not fully understood. Here we provide evidence that association of th...

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Autors principals: Wang, Feng, Li, Geng, Altaf, Mohammed, Lu, Chenning, Currie, Mark A., Johnson, Aaron, Moazed, Danesh
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666683/
https://ncbi.nlm.nih.gov/pubmed/23650358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300126110
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