Formulation and In Vivo Evaluation of Orally Disintegrating Tablets of Clozapine/Hydroxypropyl-β-cyclodextrin Inclusion Complexes

The aim of this study was to improve the solubility and oral bioavailability of clozapine (CLZ), a poorly water-soluble drug subjected to substantial first-pass metabolism, employing cyclodextrin complexation technique. The inclusion complexes were prepared by an evaporation method. Phase solubility...

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Bibliographic Details
Main Authors: Zeng, Fan, Wang, Ling, Zhang, Wenjing, Shi, Kejing, Zong, Li
Format: Artigo
Language:Inglês
Published: Springer US 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3666014/
https://ncbi.nlm.nih.gov/pubmed/23649995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-013-9973-x
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