Association of a Genetic Variation in a miR-191 Binding Site in MDM4 with Risk of Esophageal Squamous Cell Carcinoma

As an oncoprotein, MDM4 plays a key part in P53 tumor suppressor pathway through negatively regulating P53 function. It has been reported that an rs4245739 A>C polymorphism locating in the MDM4 3′-untranslated region creates a miR-191 target site and results in decreased MDM4 expression. Therefor...

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Autores principales: Zhou, Liqing, Zhang, Xiaojiao, Li, Ziqiang, Zhou, Changchun, Li, Meng, Tang, Xiaohu, Lu, Chao, Li, Helou, Yuan, Qipeng, Yang, Ming
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665831/
https://ncbi.nlm.nih.gov/pubmed/23724042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064331
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