Ligand Binding Reduces Conformational Flexibility in the Active Site of Tyrosine Phosphatase Related to Biofilm Formation A (TpbA) from Pseudomonas aeruginosa

TpbA is a periplasmic dual specificity phosphatase (DUSP) that controls biofilm formation in the pathogenic bacterium, Pseudomonas aeruginosa. While DUSPs are known to regulate important cellular functions in both prokaryotes and eukaryotes, very few structures of bacterial DUSPs are available. Here...

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Hauptverfasser: Koveal, Dorothy, Clarkson, Michael W., Wood, Thomas K., Page, Rebecca, Peti, Wolfgang
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665656/
https://ncbi.nlm.nih.gov/pubmed/23524133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.03.023
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