LACK OF SIGMA-1 RECEPTOR EXACERBATES ALS PROGRESSION IN MICE

The function of the sigma-1 receptor (S1R) has been implicated in modulating the activity of various ion channels. In the Central Nervous System (CNS) S1R is enriched in cholinergic postsynaptic densities in spinal cord motoneurons (MN). Mutations in S1R have been found in familial cases of Amyotrop...

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Detalhes bibliográficos
Main Authors: Mavlyutov, Timur A., Epstein, Miles L., Verbny, Yakov I., Huerta, Maria S., Zaitoun, Ismail, Ziskind-Conhaim, Lea, Ruoho, Arnold E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665351/
https://ncbi.nlm.nih.gov/pubmed/23458708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2013.02.035
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