Regulation of De Novo Ceramide Synthesis: The Role of Dihydroceramide Desaturase and Transcriptional Factors NFATC and Hand2 in the Hypoxic Mouse Heart

We have previously shown that ceramide, a proapoptotic molecule decreases in the mouse heart as it adapts to hypoxia. We have also shown that its precursor, dihydroceramide, accumulates with hypoxia. This implicates the enzyme dihydroceramide desaturase (DHC-DS), which converts dihydroceramide to ce...

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Detalhes bibliográficos
Main Authors: Azzam, Raed, Hariri, Fadi, El-Hachem, Nehmé, Kamar, Amina, Dbaibo, Ghassan, Nemer, Georges, Bitar, Fadi
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Protein Expression/Modification/Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3665309/
https://ncbi.nlm.nih.gov/pubmed/23672204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/dna.2013.1993
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