How Biochemical Constraints of Cellular Growth Shape Evolutionary Adaptations in Metabolism

Evolutionary adaptations in metabolic networks are fundamental to evolution of microbial growth. Studies on unneeded-protein synthesis indicate reductions in fitness upon nonfunctional protein synthesis, showing that cell growth is limited by constraints acting on cellular protein content. Here, we...

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Bibliografske podrobnosti
Main Authors: Berkhout, Jan, Bosdriesz, Evert, Nikerel, Emrah, Molenaar, Douwe, de Ridder, Dick, Teusink, Bas, Bruggeman, Frank J.
Format: Artigo
Jezik:Inglês
Izdano: Genetics Society of America 2013
Teme:
Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664859/
https://ncbi.nlm.nih.gov/pubmed/23535382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.150631
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