Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis

Bacillus subtilis has two replicative DNA polymerases. PolC is a processive high-fidelity replicative polymerase, while the error-prone DnaE(Bs) extends RNA primers before hand-off to PolC at the lagging strand. We show that DnaE(Bs) interacts with the replicative helicase DnaC and primase DnaG in a...

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Autores principales: Rannou, Olivier, Le Chatelier, Emmanuelle, Larson, Marilynn A., Nouri, Hamid, Dalmais, Bérengère, Laughton, Charles, Jannière, Laurent, Soultanas, Panos
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664799/
https://ncbi.nlm.nih.gov/pubmed/23563155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt207
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