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The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition

One of the most important mechanisms that promotes metastasis is the stabilization of Hif-1 (hypoxia-inducible transcription factor 1). We decided to test whether Hif-1α also was required for early embryonic development. We focused our attention on the development of the neural crest, a highly migra...

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Bibliographic Details
Main Authors: Barriga, Elias H., Maxwell, Patrick H., Reyes, Ariel E., Mayor, Roberto
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664719/
https://ncbi.nlm.nih.gov/pubmed/23712262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201212100
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