PPAR-Alpha Agonists as Novel Antiepileptic Drugs: Preclinical Findings

Nicotinic acetylcholine receptors (nAChRs) are involved in seizure mechanisms. Hence, nocturnal frontal lobe epilepsy was the first idiopathic epilepsy linked with specific mutations in α4 or β2 nAChR subunit genes. These mutations confer gain of function to nAChRs by increasing sensitivity toward a...

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Detalhes bibliográficos
Main Authors: Puligheddu, Monica, Pillolla, Giuliano, Melis, Miriam, Lecca, Salvatore, Marrosu, Francesco, De Montis, Maria Graziella, Scheggi, Simona, Carta, Gianfranca, Murru, Elisabetta, Aroni, Sonia, Muntoni, Anna Lisa, Pistis, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664607/
https://ncbi.nlm.nih.gov/pubmed/23724059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064541
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