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Parallel declines in cognition, motivation, and locomotion in aging mice: association with immune gene upregulation in the medial prefrontal cortex

Aging in humans is associated with parallel changes in cognition, motivation, and motoric performance. Based on the human aging literature, we hypothesized that this constellation of age-related changes is mediated by the medial prefrontal cortex and that it would be observed in aging mice. Toward t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bordner, Kelly A., Kitchen, Robert R., Carlyle, Becky, George, Elizabeth D., Mahajan, Milind C., Mane, Shrikant M., Taylor, Jane R., Simen, Arthur A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3664302/
https://ncbi.nlm.nih.gov/pubmed/21453768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2011.03.003
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