Suppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell “Dormancy”

A major problem in cancer research is the lack of a tractable model for delayed metastasis. Herein we show that cancer cells suppressed by SISgel, a gel-forming normal ECM material derived from Small Intestine Submucosa (SIS), in flank xenografts show properties of suppression and re-activation that...

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Detalhes bibliográficos
Main Authors: Hurst, Robert E., Hauser, Paul J., Kyker, Kimberly D., Heinlen, Jonathan E., Hodde, Jason P., Hiles, Michael C., Kosanke, Stanley D., Dozmorov, Mikhail, Ihnat, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663841/
https://ncbi.nlm.nih.gov/pubmed/23717563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064181
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