The Fish Pathogen Yersinia ruckeri Produces Holomycin and Uses an RNA Methyltransferase for Self-resistance

Holomycin and its derivatives belong to a class of broad-spectrum antibacterial natural products containing a rare dithiolopyrrolone heterobicyclic scaffold. The antibacterial mechanism of dithiolopyrrolone compounds has been attributed to the inhibition of bacterial RNA polymerase activities, altho...

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Autori principali: Qin, Zhiwei, Baker, Alexander Thomas, Raab, Andrea, Huang, Sheng, Wang, Tiehui, Yu, Yi, Jaspars, Marcel, Secombes, Christopher J., Deng, Hai
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663494/
https://ncbi.nlm.nih.gov/pubmed/23572522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448415
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