Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasms

We studied mutations of MPL exon 10 in patients with essential thrombocythemia (ET) or primary myelofibrosis (PMF), first investigating a cohort of 892 consecutive patients. MPL mutation scanning was performed on granulocyte genomic DNA by using a high-resolution melt assay, and the mutant allele bu...

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Autors principals: Rumi, Elisa, Pietra, Daniela, Guglielmelli, Paola, Bordoni, Roberta, Casetti, Ilaria, Milanesi, Chiara, Sant’Antonio, Emanuela, Ferretti, Virginia, Pancrazzi, Alessandro, Rotunno, Giada, Severgnini, Marco, Pietrelli, Alessandro, Astori, Cesare, Fugazza, Elena, Pascutto, Cristiana, Boveri, Emanuela, Passamonti, Francesco, De Bellis, Gianluca, Vannucchi, Alessandro, Cazzola, Mario
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663431/
https://ncbi.nlm.nih.gov/pubmed/23575445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-02-486050
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