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Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications

The ability to deliver drug molecules effectively across the blood–brain barrier into the brain is important in the development of central nervous system (CNS) therapies. Cerebral microdialysis is the only existing technique for sampling molecules from the brain extracellular fluid (ECF; also termed...

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Detalhes bibliográficos
Main Authors: Shannon, Richard J., Carpenter, Keri L. H., Guilfoyle, Mathew R., Helmy, Adel, Hutchinson, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663257/
https://ncbi.nlm.nih.gov/pubmed/23468415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-013-9306-4
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