Increased Intragenic IGF2 Methylation is Associated with Repression of Insulator Activity and Elevated Expression in Serous Ovarian Carcinoma

Overexpression of insulin-like growth factor-II (IGF2) is a prominent characteristic of many epithelial ovarian malignancies. IGF2 imprinting and transcription are regulated in part through DNA methylation, which in turn regulates binding of the insulator protein CTCF within the IGF2/H19 imprint cen...

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Bibliographic Details
Main Authors: Huang, Zhiqing, Murphy, Susan K.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Oncology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662894/
https://ncbi.nlm.nih.gov/pubmed/23745176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2013.00131
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