Human tRNA(Lys3)(UUU) is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto-EnolTautomerism

Human tRNA(Lys3)(UUU) (htRNA(Lys3)(UUU)) decodes the lysine codons AAA and AAG during translation, and also plays a crucial role as the primer for HIV-1 reverse transcription. The post-transcriptional modifications 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U(34)), 2-methylthio-N(6)-threonylca...

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Main Authors: Vendeix, Franck A. P., Murphy, Frank V., Cantara, William A., Leszczyńska, Grażyna, Gustilo, Estella M., Sproat, Brian, Malkiewicz, Andrzej, Agris, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3662832/
https://ncbi.nlm.nih.gov/pubmed/22227389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.048
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