Protein aggregation in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have identified several new molecular constituents of ALS-linked cellular aggregates, including FUS, TDP-43, OPTN, UBQLN2 and the tr...

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Bibliografiske detaljer
Main Authors: Blokhuis, Anna M., Groen, Ewout J. N., Koppers, Max, van den Berg, Leonard H., Pasterkamp, R. Jeroen
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2013
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3661910/
https://ncbi.nlm.nih.gov/pubmed/23673820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1125-6
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